TB-500
Also known as: Thymosin Beta-4 fragment, Tβ4 (17–23), Thymosin β4
A synthetic version of the naturally occurring actin-sequestering protein thymosin beta-4. Promotes tissue repair, reduces inflammation, and enhances cell migration.
Available from Nexis Labs
BPC 157 + TB-500
Sizes: 10mg/10mg
From $110.99
Overview
TB-500 is typically a synthetic fragment of thymosin beta-4 (Tβ4), a ubiquitous intracellular protein involved in the regulation of actin polymerization. Full-length Tβ4 is found in virtually every cell in the body and plays a central role in wound healing, tissue repair, and inflammation resolution. TB-500 (the Tβ4 17–23 fragment) retains much of the regenerative activity of the full protein at a fraction of the molecular weight.
Research in horses (where it is sometimes used under veterinary context) and in rodent models has shown TB-500 to significantly accelerate healing of tendons, muscle tears, and skin wounds. It works in a complementary fashion to BPC-157, targeting different but overlapping repair pathways, which is why they are frequently studied in combination. Thymosin beta-4 is also of interest for cardiac repair, as it promotes cardiomyocyte survival in models of myocardial infarction.
Mechanism of Action
TB-500 binds to G-actin via its LKKTETQ sequence, regulating actin dynamics and enabling cell migration into wound sites. It promotes upregulation of metalloproteinases, angiogenesis, and stem cell differentiation. Its anti-inflammatory effects are partly mediated through downregulation of NF-κB and inflammatory cytokine expression.
Research Areas
- ●Tendon and ligament repair
- ●Muscle healing and regeneration
- ●Cardiac tissue repair after ischemia
- ●Skin wound healing
- ●Stem cell mobilization research
- ●Neurological recovery models
- ●Anti-inflammatory research
Storage & Handling
Lyophilized: -20°C. Reconstituted: 2–8°C, up to 28 days.
Soluble in sterile water or bacteriostatic water
For Research Use Only. This information is provided for educational and research purposes. TB-500 is not approved for human consumption, veterinary use, or clinical application. All research must be conducted in accordance with applicable laws and institutional guidelines.