Ipamorelin
Also known as: Ipamorelin acetate
A selective growth hormone secretagogue and ghrelin receptor agonist. Considered one of the cleanest GHS peptides due to its minimal effect on cortisol and prolactin.
Available from Nexis Labs
Ipamorelin
Sizes: 10mg
From $89.99
Overview
Ipamorelin is a pentapeptide that selectively stimulates growth hormone release from the pituitary gland. Unlike earlier GHS compounds, ipamorelin does not significantly increase cortisol, aldosterone, or prolactin, making it a subject of considerable research interest. It was originally developed by Novo Nordisk and has been studied extensively in preclinical models.
In research settings, ipamorelin is frequently combined with CJC-1295 (a GHRH analogue) to produce synergistic pulses of GH release that more closely mimic physiological patterns. Its clean safety profile in animal studies has made it one of the most widely researched GHSR agonists.
Mechanism of Action
Ipamorelin mimics the endogenous hormone ghrelin by binding to the growth hormone secretagogue receptor (GHSR-1a) in the pituitary and hypothalamus. This binding triggers a pulse of GH release without significantly affecting the hypothalamic-pituitary-adrenal axis. It also works synergistically with endogenous GHRH to amplify GH pulses.
Research Areas
- ●Growth hormone deficiency models
- ●Bone density and skeletal growth studies
- ●Lean body mass and body composition research
- ●Sleep quality and recovery investigation
- ●GI motility research (post-operative ileus models)
- ●Aging and longevity research
Storage & Handling
Store lyophilized powder at -20°C. Once reconstituted, refrigerate at 2–8°C and use within 28 days.
Soluble in sterile water or bacteriostatic water
For Research Use Only. This information is provided for educational and research purposes. Ipamorelin is not approved for human consumption, veterinary use, or clinical application. All research must be conducted in accordance with applicable laws and institutional guidelines.