Hexarelin
Also known as: Examorelin, EP-23905, MF-6003
One of the most potent synthetic GHSR agonists. Notable for strong GH release and significant research interest in cardiac protection independent of GH effects.
Overview
Hexarelin is a six-amino acid synthetic peptide with among the highest binding affinity for GHSR-1a of any synthetic GHS compound. It produces robust GH pulses that tend to desensitize with repeated administration, a phenomenon extensively studied in GH secretion dynamics research. Its GH-stimulating potency surpasses GHRP-2 and GHRP-6 on a molar basis.
Beyond its role as a GHS, hexarelin has attracted research attention for its cardioprotective properties. Studies in animal models have shown it can bind to the CD36 scavenger receptor independently of the GHSR, mediating direct cardiac effects including reduced apoptosis in ischemic conditions. This GH-independent cardiac activity distinguishes hexarelin from other GHRP class peptides.
Mechanism of Action
Hexarelin is a high-affinity GHSR-1a agonist that triggers strong pulsatile GH release via pituitary and hypothalamic pathways. Uniquely, it also binds to the CD36 receptor on cardiac cells and macrophages, activating PI3K/Akt signaling pathways associated with cardioprotection, independent of any GH-mediated effects.
Research Areas
- ●GH secretion dynamics and tachyphylaxis
- ●Cardioprotective effects in ischemia models
- ●CD36 receptor biology
- ●Body composition research
- ●Neuroprotection studies
- ●GH/IGF-1 axis pharmacology
Storage & Handling
Lyophilized: -20°C. Reconstituted: 2–8°C, 14–28 days.
Soluble in sterile water or dilute acetic acid
For Research Use Only. This information is provided for educational and research purposes. Hexarelin is not approved for human consumption, veterinary use, or clinical application. All research must be conducted in accordance with applicable laws and institutional guidelines.