GHK-Cu
Also known as: Copper peptide, Copper tripeptide-1, Glycyl-L-histidyl-L-lysine copper
A naturally occurring copper-binding tripeptide found in human plasma. Extensively studied for skin regeneration, wound healing, and anti-aging effects through gene activation.
Available from Nexis Labs
GHK-CU
Sizes: 100mg
From $99.99
Overview
GHK-Cu is a tripeptide (Gly-His-Lys) that naturally complexes with copper(II) ions and is found in plasma, urine, and saliva. Its concentration declines significantly with aging — from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60 — a drop correlated with age-related decline in tissue repair capacity. It is one of the most studied peptides in dermatology and regenerative medicine.
GHK-Cu has been shown to activate a range of genes involved in wound healing, collagen synthesis, antioxidant defense, and anti-inflammatory signaling. Remarkably, transcriptomic analyses suggest it can reset a significant portion of age-altered gene expression back toward a younger pattern. Its dual role as both a wound-healing accelerator and a potential systemic anti-aging molecule has made it a subject of renewed interest in longevity research.
Mechanism of Action
GHK-Cu stimulates collagen, elastin, glycosaminoglycan, and proteoglycan synthesis in fibroblasts. It activates metalloproteinases that remove damaged collagen and simultaneously promotes new ECM deposition. It modulates SPARC, TGF-β, and VEGF pathways. As a copper chaperone, it also enhances the activity of copper-dependent antioxidant enzymes (SOD).
Research Areas
- ●Skin aging and collagen remodeling
- ●Wound healing acceleration
- ●Hair follicle stimulation
- ●Anti-inflammatory and antioxidant research
- ●Gene expression reprogramming in aging
- ●Nerve regeneration studies
- ●Lung and GI tissue protection
Storage & Handling
Lyophilized: -20°C. Reconstituted: 2–8°C, use within 28 days. Protect from light.
Soluble in sterile water; the copper complex is a blue-green color
For Research Use Only. This information is provided for educational and research purposes. GHK-Cu is not approved for human consumption, veterinary use, or clinical application. All research must be conducted in accordance with applicable laws and institutional guidelines.