Epithalon

Overview

Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, derived from the natural peptide fraction epithalamin isolated from bovine pineal glands. It has been the subject of research for over four decades, primarily in Russian scientific institutions, and is perhaps the most studied peptide in the context of lifespan extension.

Animal studies (in fruit flies, mice, and rats) have reported life extension of 25–40% with chronic epithalon treatment. Human clinical trials conducted in Russia over the 1990s–2000s reported reductions in biomarkers of aging in elderly patients. The compound's most discussed mechanism is the stimulation of telomerase activity — the enzyme responsible for maintaining telomere length — which has led to significant interest in the longevity research community.

Mechanism of Action

Epithalon activates telomerase (hTERT), the enzyme that synthesizes telomeric DNA repeats, potentially slowing telomere shortening with each cell division. It also normalizes neuroendocrine function through the pineal gland, regulates melatonin secretion cycles, and has been reported to restore circadian rhythm disruptions. Additional mechanisms include antioxidant activity and modulation of PCNA (proliferating cell nuclear antigen).

Research Areas

• ●Telomere biology and telomerase activation
• ●Lifespan extension in animal models
• ●Circadian rhythm and melatonin regulation
• ●Cancer cell inhibition research
• ●Retinal aging and macular degeneration
• ●Neuroendocrine function in aging

Storage & Handling

For Research Use Only. This information is provided for educational and research purposes. Epithalon is not approved for human consumption, veterinary use, or clinical application. All research must be conducted in accordance with applicable laws and institutional guidelines.